mid-14c., from Middle French désperation or directly from Latin desperationem (nominative desperatio) "despair, hopelessness," noun of action from past participle stem of desperare "lose hope" (see despair (v.)).
1. Frustration, anger and desperation have led to a series of wildcat strikes.
2. In desperation I changed tack.
3. In desperation I joined a physical exercise class.
4. In desperation , she called Louise and asked for her help.
5. In his desperation to escape, Tom had slipped and broken a leg.