PyoudaoicibaDictYouDict
a rare letter in the initial position in Germanic, in part because by Grimm's Law PIE p- became Germanic f-; even with the early Latin borrowings in Old English, -p- takes up a little over 4 pages in J.R. Clark Hall's "Concise Anglo-Saxon Dictionary," compared to 31 pages for B and more than 36 for F. But it now is the third-most-common initial letter in the English vocabulary, and with C and S comprises nearly a third of the dictionary, a testimony to the flood of words that have entered the language since 1066 from Latin, Greek, and French.

To mind one's Ps and Qs (1779), possibly is from confusion of these letters among children learning to write. Another theory traces it to old-time tavern-keepers tracking their patrons' bar tabs in pints and quarts. But see also to be P and Q (1610s), "to be excellent," a slang phrase said to derive from prime quality.
sh-youdaoicibaDictYouDict
sound represented in Old English by -sc- (fisc "fish"), which originally was pronounced "-sk-" but which by late Old English had softened to "-sh-." Modern English words with -sc- mostly are imports (generally Scandinavian).

The "sh" sound did not exist in Old French, therefore French scribes after the Norman conquest often represented it with -ssh- in medial and final positions, and sch- in initial positions (schape, schamful, schaft for shape, shameful, shaft). But the spelling -sh- has been standard since Caxton, probably as a worn-down form of Middle English -sch-.

In some East Anglian texts from 14c.-15c., x- is used (xal, xulde for shall, should), which would have given the language a very different look had it prevailed, but the London-based sh- ended up as the standard form. The same Germanic sound has become, by natural evolution, modern German and Dutch sch-, Scandinavian sk-.