depress (v.)youdaoicibaDictYouDict[depress 词源字典]
early 14c., "put down by force," from Old French depresser, from Late Latin depressare, frequentative of Latin deprimere "press down," from de- "down" (see de-) + premere "to press" (see press (v.1)). Meaning "push down physically" is from early 15c.; that of "deject, make gloomy" is from 1620s; economic sense of "lower in value" is from 1878. Related: Depressed; depressing.[depress etymology, depress origin, 英语词源]
downer (n.)youdaoicibaDictYouDict
1966 in sense of "barbiturate;" 1970 in sense of "depressing person;" agent noun from down (v.).
nostalgia (n.)youdaoicibaDictYouDict
1770, "severe homesickness considered as a disease," Modern Latin, coined 1668 in a dissertation on the topic at the University of Basel by scholar Johannes Hofer (1669-1752) as a rendering of German heimweh (for which see home + woe). From Greek algos "pain, grief, distress" (see -algia) + nostos "homecoming," from PIE *nes- "to return safely home" (cognate with Old Norse nest "food for a journey," Sanskrit nasate "approaches, joins," German genesen "to recover," Gothic ganisan "to heal," Old English genesen "to recover"). French nostalgie is in French army medical manuals by 1754.

Originally in reference to the Swiss and said to be peculiar to them and often fatal, whether by its own action or in combination with wounds or disease. By 1830s the word was used of any intense homesickness: that of sailors, convicts, African slaves. "The bagpipes produced the same effects sometimes in the Scotch regiments while serving abroad" [Penny Magazine," Nov. 14, 1840]. It is listed among the "endemic diseases" in the "Cyclopaedia of Practical Medicine" [London, 1833, edited by three M.D.s], which defines it as "The concourse of depressing symptoms which sometimes arise in persons who are absent from their native country, when they are seized with a longing desire of returning to their home and friends and the scenes their youth ...." It was a military medical diagnosis principally, and was considered a serious medical problem by the North in the American Civil War:
In the first two years of the war, there were reported 2588 cases of nostalgia, and 13 deaths from this cause. These numbers scarcely express the real extent to which nostalgia influenced the sickness and mortality of the army. To the depressing influence of home-sickness must be attributed the fatal result in many cases which might otherwise have terminated favorably. ["Sanitary Memoirs of the War," U.S. Sanitary Commission, N.Y.: 1867]
Transferred sense (the main modern one) of "wistful yearning for the past" first recorded 1920, perhaps from such use of nostalgie in French literature. The longing for a distant place also necessarily involves a separation in time.
neurolepticyoudaoicibaDictYouDict
"(Of a drug) tending to reduce nervous tension by depressing nerve functions", 1950s: from neuro- 'relating to nerves' + -leptic, as in organoleptic.