1. Method:Tubulointerstitial fibrosis model was established by unilateral ureteral obstruction(UUO) rat.
方法:采用单侧输尿管梗阻(UUO)诱导大鼠肾小管间质纤维化模型。

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2. Methods The animal model of renal disease was induced by unilateral ureteral obstruction (UUO) in CD-1 mice.
方法采用左侧输尿管结扎的方法建立单侧输尿管梗阻(UUO)雄性CD-1小鼠动物模型。

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3. UUO group rats received an operation with left ureteral obstruction below the renal pelvis and were also gavaged with saline daily;
单侧输尿管梗阻组(U):大鼠行手术剖腹,分离并于肾盂下结扎左侧输尿管,同时术前一天开始每日给以安慰剂生理盐水灌胃处理;

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4. Objective To investigate the effects of geranylgeranylacetone (GGA) on tubulointerstitiai fibrosis in unilateral ureteral obstruction (UUO) rats.
目的探讨替普瑞酮(GGA)对大鼠梗阻性肾病模型(UUO)肾间质纤维化的影响和可能机制。

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5. Objective To study the protective effects of Shenyankangfu tablet on renal interstitial fibrosis in rats with unilateral ureteral obstruction (UUO).
目的:研究肾炎康复片对单侧输尿管梗阻(uuo)大鼠肾间质纤维化的保护作用。

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6. Objective: To study the effects of "Kangxian Ling Decoction" (KLD) on renal interstitial fibrosis induced by unilateral ureteral obstruction (UUO) in rats.
目的:探讨中药抗纤灵方对大鼠单侧输尿管结扎(UUO)所致肾纤维化的防治作用及机制。

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7. To evaluate the effect of estrogen on tubular epithelial cell phenotype transdifferentiation of tubulointerstitial fibrosis in unilateral ureteral obstruction(UUO)rats.
目的探讨雌激素在单侧输尿管梗阻(UUO)大鼠肾间质纤维化模型中对肾小管上皮细胞表型转化的影响。

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8. Estrogen can prevent the development of interstitial fibrosis, the mechanism may with it restrain the tubular epithelial cell phenotype transdifferentiation in UUO rats.
结论雌激素可能通过抑制UUO大鼠肾小管上皮细胞表型转化而发挥延缓肾间质纤维化的作用。

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9. Purpose To observe whether hypoxia exists in the obstructed kidney of unilateral ureteral obstruction (UUO) rat model and its distribution relationship with tubulointerstitial fibrosis.
目的证实结扎致单侧输尿管梗阻(uuo)大鼠模型梗阻侧肾脏是否存在低氧,不同时间点低氧的特点及低氧与肾间质纤维化的关系。

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10. Conclusion the pharmacological effects of curcumin and enalapril may be partly mediated by inhibiting the transdifferentiation of renal tubular epithelial cells towards myofibroblast in UUO rats.
结论姜黄素及依那普利可能通过抑制UUO大鼠肾小管上皮细胞转分化而减轻肾间质纤维化。

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11. Conclusion the pharmacological effects of curcumin and enalapril may be partly mediated by inhibiting the transdifferentiation of renal tubular epithelial cells towards myofibroblast in UUO rats.
结论姜黄素及依那普利可能通过抑制UUO大鼠肾小管上皮细胞转分化而减轻肾间质纤维化。

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