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go off (v.)
1570s, of firearms, etc., "explode, be discharged;" see
go
(v.) +
off
(adv.); meaning "depart" is c. 1600; that of "deteriorate in condition" is from 1690s; that of "reprimand" is from 1941 (originally with
at
, since c. 2000 more often with
on
).